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L-Theanine (Camellia sinensis O. Ktze.)

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Abstract:

Common Name: Suntheanine, Green Tea Extract
Part Used: Leaf
CAS No.: 3081-61-6
Specification: L-Theanine 20% ~ 98% 

Description:

L-Theanine is a non-protein amino acid mainly extracted from green tea, it is the predominant amino acid in green tea. L-theanine is considered the main component responsible for the taste of green tea, L-Theanine is a nutritional supplement for mood modulation. It inhibits glutamate transport into tumor cells, which causes decreased intracellular glutathione (GSH) levels. L-Theanine may have activity in modulating the metabolism of cancer chemotherapeutic agents and ameliorating their side effects.

Functions:

1. The antioxidant activity; anti-cancer;
2. In the brain L-Theanine increases dopamine and serotonin production;
3. L-Theanine may counteract the stimulatory effect of caffeine;
4. L-Theanine induces alpha-brain wave activity, which correlates with a perceived state of relaxation.
5. L-Theanine helps curb a rising heart rate and blood pressure, and a few small human studies have found that it reduces anxiety;
6. L-Theanine increases the activity of doxorubicin, idarubicin, pirarubicin, cisplatin, and irinotecan in tumor cells.

Side Effects and Toxicity:

L-Theanine is generally well tolerated, and has an LD50 of greater than 5,000 mg/kg in rats. It is not mutagenic or carcinogenic in animals or bacteria.

Dosage and Administration:

For relaxation, 200 mg L-Theanine can be taken 2-3 times daily. For cancer in conjunction with chemotherapy the dose is speculative, as no human studies have been performed. However, a dosage of 400-800 mg three times daily can be used safely.

 

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